经典信号通路之PI3K AKT信号通路
经典信号通路之PI3K/AKT信号通路
日期：2012-03-12 来源：未知 标签： PI3K/AKT
摘要 : The PI3K/AKT and related pathways are important in internalizing the effects of external growth factors and of membrane tyrosine kinases.
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The PI3K/AKT and related pathways are important in inteRNAlizing the effects of
external growth factors and of membrane tyrosine kinases. Activation of membrane kinases including epidermal growth factor receptor (EGFR) by external growth factors initiates receptor dimerization and subsequent events to activate these intracellular pathways. AKT is activated downstream of PI3K and has multiple targets. AKT and the cellular energy sensors LKB1 (STK11) and AMP-activated protein kinase (AMPK) exert opposing effects on mammalian target of rapamycin (mTOR), which is activated by AKT. ERK, extracellular signal regulated kinase; FKHR, forkhead; GDP, guanosine
