小鼠淋巴结分布

小鼠淋巴结分布

JournalofImmunologicalMethods312(2006)12–

小鼠淋巴结分布

小鼠淋巴结分布

19

Researchpaper

Anatomyandnomenclatureofmurinelymphnodes:DescriptivestudyandnomenclatorystandardizationinBALB/cAnNCrlmice

WimVandenBroecka, ,AnnieDeroreb,c,PaulSimoensa

a

DepartmentofMorphology,FacultyofVeterinaryMedicine,GhentUniversity,Salisburylaan133,B-9820Merelbeke,Belgium

b

InnogeneticsNV,IndustrieparkZwijnaarde7,B-9052Ghent,Belgium

c

FlandersInteruniversityInstituteforBiotechnology(VIB),Technologiepark927,B-9052Ghent,Belgium

Received21November2005;receivedinrevisedform10January2006;accepted26January2006

Availableonline6March2006

Abstract

Murinelymphnodesareintensivelystudiedbutoftenassignedincorrectlyinscientificpapers.InBALB/cAnNCrlmice,wecharacterizedatotalof22differentlymphnodes.Peripheralnodesweresituatedintheheadandneckregion(mandibular,accessorymandibular,superficialparotid,cranialdeepcervicalnodes),andattheforelimb(properaxillary,accessoryaxillarynodes)andhindlimb(subiliac,sciatic,poplitealnodes).Intrathoraciclymphnodesincludedthecranialmediastinal,tracheobronchalandcaudalmediastinalnodes.Abdominallymphnodeswereassociatedwiththegastrointestinaltract(gastric,pancreaticoduodenal,jejunal,colic,caudalmesentericnodes)orwerelocatedalongthemajorintra-abdominalbloodvessels(renal,lumbaraortic,lateraliliac,medialiliacandexternaliliacnodes).Comparativeandnomenclativeaspectsofmurinelymphnodesarediscussed.ThepositionofthelymphnodesofBALB/cAnNCrlmiceissummarizedandillustratedinananatomicalchartcontainingproposalsforbothanofficialnomenclatureaccordingtotheNominaAnatomicaVeterinariaandEnglishterms.©2006ElsevierB.V.Allrightsreserved.

Keywords:Mouse;Lymphnode;Nomenclature

1.Introduction

Rodents,andmiceinparticular,havelongbeenusedaslaboratoryanimalsinvariousscientificexperiments.Thepossibilitytoproducedifferentmurinestrainsandavarietyofknock-outmice,thehighreproductiverateoftheseanimals,andtheeaseoftheirhandlinghavemadethemthepreferentiallaboratoryanimal.Inimmunolog-icalsciences,murinelymphnodes(lnn.)areoftenusedtoisolatelymphocytesinordertostudyfundamental

Correspondingauthor.Tel.:+3292747716;fax:+3292647790.E-mailaddress:wim.vandenbroeck@UGent.be(W.VandenBroeck).

0022-1759/$-seefrontmatter©2006ElsevierB.V.Allrightsreserved.doi:10.1016/j.jim.2006.01.022

aspectsofimmunologyandimmunopathology.Themethodologytorecognizeanddissecttheselymphnodesrequiresatleastabasicanatomicalknowledge.Innumerousstudies,however,inaccurate,misleadingorevenenigmatictermssuchasgenitalnodes(CainandRank,1995)ortonsillarnodes(Deaglioetal.,1996)havesometimesbeenassignedtomurinelymphnodes.Theambiguityofmurinelymphnode(ln.)nomenclatureisillustratedbythelymphnodeattheearbaseofmicewhichhasbeenvariablydesignatedbyvarioustermssuchasparotidln.(Cuq,1966;Grassé,1972;Popeskoetal.,1992),lateralmandibularln.(Cuq,1966),andfacialln.(Wolversetal.,1999),whilenumerousrecentstudiesrefertoanallegedlyauricularln.(Anjuèreetal.,1999;Dearmanetal.,1996;Sailstadetal.,1995)orpre-

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